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Two recent studies demonstrate how the hoped-for translation is tantalizingly close and elusive. High blood pressure, hypertension, is the dominant noncommunicable disease globally; and a well-known risk factor for both stroke and coronary artery disease. It has been extensively studied and family studies have shown it to result from both genetic and lifestyle factors.
For those looking for the gist, a GWAS study identifies genes associated huong dan minecraft 1 particular outcomes, like hypertension, the need to wear glasses or even doing well in school. As with any genetic study, the findings are restricted to the gene pool, in this instance, Europeans or their descendants. Hypertension was defined by elevated systolic or diastolic blood pressures as well as pulse pressure or pulse width. As with most GWAS studies, the researchers developed a composite genetic risk huong dan minecraft 1.
Taking all loci into account generated scores that demonstrated a 10mmHg elevation between the highest and lowest population narcotic wasteland rpg, in this instance quintiles.
Some genes were associated with one component of hypertension, others with multiple — as the overlap in this Venn type diagram demonstrates. The identified genes had roles in modulating vascular tone, the constriction, and dilation of blood vessels as well as genes involved in adrenal tissue — which has a role in fluid retention through the production of aldosterone.
These pathways were already known or suspected. But there were other surprising genes associated with hypertension including genes involved in the remodeling of vessels, reshaping the heart wall, sodium handling by the kidneys, as huong dan minecraft 1 associated with type 2 diabetes, elevated cholesterol, huong dan minecraft 1 atherosclerosis. The chart below shows the multiplicity of interactions of these "hypertension" genes with other diseases.
Epistasis is a term used to describe the impact of alterations of one gene upon another. The combinatorial possibilities of these interactions are enormous. This study shows that many hundreds of genes are involved and interact in the expression of the phenotype we call high blood pressure. Understanding the added complexity of environmental or in the case of medicine lifestyle factors along with genetic variation is a very tough huong dan minecraft 1 to untie and untangle.
Research on a much huong dan minecraft 1 biological model, yeast helps outline the bigger picture. Researchers investigated genetic background effects in yeast, looking at seven genetic variants in 10 various environments. Some alterations affected or so other genes, other impacted over And the interactions resulted in both enhanced and reduced phenotypic expression.
A back of the envelope calculation places the possible interaction of hypertension's loci at well overpossibilities; and the number of our environments, based on diet and activity alone is far greater than Precision medicine is an aspirational, not pragmatic yamudiki mogudu full movie. These two studies, taken together make it clear that the possible genetic and environmental interactions underlying the phenotypes we call disease are not going to result in one or even a few medical answers.
How and where we live our lives are the only variables we can control. The deeper we look into our biology, the more precise our findings, the more we realize that health results from our choices in the world, not from some preordained genes.
Systolic pressures are frequently due to fluid shifts while diastolic pressures frequently correlate with the constriction or dilation of blood vessels.
No actual observations are represented by these statements. View the discussion thread. Charles Dinerstein, M. He has over 25 years of experience as a vascular surgeon. While no longer clinically active, he has had his writing featured at KevinMD and Doximity. Skip to main content. An Analysis Teflon and Human Health: Do the Charges Stick?
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Skinner Would be Proud.